The Next Generation of Pat Tools To Measure the Advance of the Sublimation Front in a Freeze-Drying Process

Industrial freeze-drying processes increasingly demand the use of wireless, battery-free, and accurate temperature sensors which allow a deeper understanding of the lyophilization process and monitor in real-time product behaviour. The new Sublime sensors aim to respond to this growing need with their wireless power transmission and communication, and multi-point measuring system consisting of five different sensors spaced within it and placed in the centre of a vial. As the primary drying is progressing, this design has proved to be a perfect solution for monitoring the advance of the sublimation front, the estimation of the sublimation rate in the vial, the sublimation endpoint with the bottom sensor and the uniformity across a batch. This study evaluates and highlights the capabilities of the Sublime sensors in a laboratory setting.