Paving the Road to Allogeneic CAR-T Therapy Manufacturing
The demand for cell and ex-vivo gene therapies is steadily increasing, given the impressive efficacy of autologous chimeric antigen receptor T-cell (CAR-T) therapies against hematological malignancies. In recent years, the reality of curative treatment and commercial approval of several autologous CAR-T products triggered developers to plan for increased capacity and treating larger patient populations. Pioneers in the CAR-T therapy space are also heavily investing in allogeneic platforms to create off-theshelf therapeutic cells that are immediately available and can treat a large number of patients with a single product batch.