Shifting the Biomanufacturing Paradigm
Intensifying Upstream Processes
This whitepaper explores several upstream strategies to increase protein titers:
Perfusion culture and media
High cell density cryopreservation
Modified amino acids
Cell...
Abstract
Today, in line with the evolution of bioprocessing techniques to satisfy the concepts on Pharma 4.0, there is heavy emphasis on cell line and expression system improvements. Against this background, the demands on bioreactors have become ever...
Abstract
Eshmuno® CP-FT resin is the first-to-market cation exchange (CEX) resin specifically developed for the flow-through removal of aggregates using frontal chromatography. In the flow-through mode, Eshmuno® CP-FT resin demonstrated that it can...
Abstract
Single-use TFF is used in biomanufacturing facilities to improve batch turnaround, process flexibility, and operator safety, all while reducing capital costs. The Pellicon® Capsule is the first of its kind — a true single-use TFF device that...
Abstract
Pharmaceutical companies face the challenge of reducing production costs without negatively affecting the quality of the finished products. HVAC systems are one of the main energy consumers in pharma facilities, especially in sterile...
Abstract
Biopharmaceutical R&D teams everywhere face the same dilemma in the development of biologics and vaccines: they must increase productivity to meet strict budgets and deadlines, while maintaining or improving data accuracy. In order to meet...
Abstract
The importance of preventing dissolved CO₂ accumulation
Controlling dissolved CO₂ measurement in mammalian cell culture processes is growing in acceptance.
dCO₂ concentration in the human body is 5% and when growing animal cells ex-vivo it is...
Abstract
Traditional tangential flow filtration (TFF) is one of the most widely used technologies in downstream bioprocessing. It can be used for concentration or diafiltration and has traditionally been operated in batch mode. Operating in batch mode...
Abstract
The most common purpose of agitation in biopharmaceutical processing is liquid/liquid and solid/liquid blend (solutions and suspensions). Agitators are performing their duty while submerged in a fluid phase, and consequently designed for this...