White Paper — Sponsored Content

In-Line Control of CO2 Accumulation to Improve Cell Culture Yield

In-Line Control of CO2 Accumulation to Improve Cell Culture Yield

In-line Control of CO2 Accumulation for Improved Cell Culture Processes

Controlling dissolved CO₂ measurement in mammalian cell culture processes is growing in acceptance. In an ex-vivo culture model, for example in a bioreactor, measuring and monitoring dCO₂ is considered critical for several reasons. dCO2 accumulation can have a substantial negative effect on cell growth, as well as on productivity and the glycosylation of the targeted protein of interest.

This white paper addresses the primary reasons for measuring dissolved dCO₂ in a bioreactor, including as a metabolic indicator, as a supplement to pH control, to manage osmolality and to ensure product quality. It then examines the specific impacts of both high concentrations of dCO₂ and low concentrations of dCO₂, regardless of bioreactor size. Lastly, it discusses methods for off-line and in-line control of dCO₂.

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