Glossary

Cancer of the prostate, a gland found only in men. The prostate surrounds the neck of the bladder and the urethra.

Organic and/or inorganic components other than amino acids, contained in proteins.

An enzyme that hydrolyzes proteins, cleaving the peptide bonds that link amino acids in protein molecules.

(IEEE) An exception that occurs when a program attempts to write into a protected area in storage.

Where, in addition to the risk of breakage of the container, freezing subjects an article to loss of strength or potency or to destructive alteration of its characteristics, the container label bears an appropriate instruction to protect the article from freezing.

Department of Education regulation that states that surveys, questionnaires and instructional materials for school children must be inspected by parents/guardians.

Biological molecules having a number of functions within, and outside the cell. They consist of amino acids arranged like a string of pearls. Genes are “blueprints” for proteins.

One of a group of substances constituting the greater part of the nitrogen-containing components of animal and vegetable tissues. They are of very complex constitution, all containing carbon, hydrogen, nitrogen, and oxygen and some containing in addition iron, phosphorous, or sulfur; chemically they are regarded as peptides (polypeptides) or combinations of amino acids and their derivatives. They are colorless, odorless, generally tasteless, and of varying degrees of solubility; they are putrefiable and readily undergo chemical change, hydrolysis, under the influence of ferments and on boiling with dilute acids or alkalis. The word was coined by J?J. Berzelius (1838) to emphasize the importance of this group of molecules.

A protein produced by the bacterium Staphylococcus aureus that specifically binds antibodies. It is useful in the purification of monoclonal antibodies.

An instrument that will determine the sequence of amino acids, which make up a particular protein.

An abnormal form of a normal cell protein, with no detectable nucleic acid, found in the brain of mammals and believed to be the agent responsible for the class of diseases called spongiform encephalopathies, including scrapie in sheep and bovine spongiform encephalopathy (BSE; mad cow disease) in cattle.

Protein hydrolysis, the decomposition of protein.

Capable of lysing (denaturing, or breaking down) proteins.

Any enzyme that takes part in the breaking down of proteins. A system of several such enzymes is necessary to break down proteins to their constituent amino acids.

The full complement of proteins produced by a particular genome.

A concept more than a defined technology, it refers to any protein-based approach that has the capacity to provide new information about proteins on a genomewide scale. 75% of the predicted proteins in multicellular organisms have no known cellular function.

(ISO) A set of semantic and syntactic rules that determines the behavior of functional units in achieving communication.

A prospective plan, that when executed as intended, produces documented evidence that a Process or System has been properly qualified.

The formal design or plan of an experiment or research activity; specifically, the plan submitted to an IRB for review and to an agency for research support. The protocol includes a description of the research design or methodology to be employed, the eligibility requirements for prospective subjects and controls, the treatment regimen(s), and the proposed methods of analysis that will be performed on the collected data.

Significant changes to the protocol that results in a new version number of the protocol. These changes may or may not affect the informed consent.

Changes or clarifications made in writing to the original protocol.

Use of pre-packaged supplies across multiple sites within a protocol managed by Interactive Response Technology and unique label content.

A semifluid, viscous, translucent mixture of water, proteins, lipids, carbohydrates, and inorganic salts found in all plant and animal cells.