Glossary

The result of the process in Functional Design (1).

Design stage where key design documents are generated to provide the framework of the detailed design process. These documents may include site plans, building floor plans, process and materials flow diagrams, air flow diagrams and HVAC schedules, rough utility and process piping routing drawings, and electrical one-line diagrams. The state HOW a facility or system is to perform.

Description of acceptance criteria, in terms of ranges and logic of system operation, etc. In HVAC, a description of HOW the HVAC will meet the acceptance criteria (room air class, DP, airflow, recovery time, level of air filtration, etc.).

Description of acceptance criteria, in terms of ranges and logic of operation etc.

Provides the functional design requirements. The FDS says how the direct impact water or steam system will perform its function. Typically, the FDS is tested or verified during commissioning or qualification.

Foods containing compounds with beneficial health effects beyond those provided by the basic nutrients, minerals and vitamins.

Biochemical assays for a specific protein, which indicates that a specific gene is not merely present but active.

The study of genomes to determine the biological function of all the genes and their products.

(IEEE) A requirement that specifies a function that a system or system component must be able to perform.

Specification document, which builds on the URS (User Requirement Specification) and provides a basic narrative on what functions the process and its control system are expected to perform.

(NIST) A specification that documents the functional requirements for a system or system component. It describes what the system or component is to do rather than how it is to be built. Often part of a requirements specification.

(IEEE) Testing that ignores the internal mechanism of a system or component and focuses solely on the outputs generated in response to selected inputs and execution conditions.

Testing conducted to evaluate the compliance of a system or component with specified functional requirements and corresponding predicted results. Synonymous: Black-Box Testing, Input/Output Driven Testing.

Suitability for the intended purpose.

Plural of fungus. Low forms of plant life unable to form protein and carbohydrates (heterotrophs) that are widespread in nature. Fungal cells are larger than bacterial cells, and their typical internal structures, such as nucleus and vacuoles, can be seen easily with a light microscope. On the basis of their mode of sexual reproduction, fungi are grouped in four classes: Phycomycetes, Ascomycetes, Deuteromycetes (Fungi Imperfectii), and Basidiomycetes. Two major groups of fungi are the yeasts and molds.

An agent that destroys fungi.

FDA Unified Registration and Listing System

The melting together of filler metal and base metal, or of base metal only, that results in coalescence.

Joining of the membrane of two cells, thus creating a daughter cell that contains some of the same properties from each parent cells. Used in making hybridomas.

A hybrid gene created by joining portions of two different genes (to produce a new protein) or by joining a gene to a different promoter (to alter or regulate gene transcription).

When making a small protein or peptide in E. coli, it is often necessary to produce the protein fused to a larger protein to get high levels of stable expression. The resulting fusion protein must be cleaved (chemically or enzymatically broken) to yield the desired protein or peptide. The nonproduct fusion partner is left over and usually discarded.

A polypeptide made from a recombinant gene that contains portions of two or more different genes. The different genes are joined so that their coding sequences are in the same reading frame: the genetic apparatus reads the gene fusion as a single gene, and so produces a fusion protein. Also known as hybrid protein or chimeric protein. These proteins are used:- to add an affinity tag to a protein;- to produce a peptide as part of a larger protein, which is then cut up after it has been made by cloning;- to produce a protein with the combined characteristics of two natural proteins; or- to produce a protein where two different activities are physically linked.