Winners in this category embody the Pharma 4.0™ concept. This includes not only implementing one or more technological innovations, but also demonstrating the ability to change their culture, processes and people orienting them towards a 4.0 future. Significant contributions include application of one or more applied science-based solutions or digital innovations like automation, robotics, digital twin, or advanced processing understanding; substantial improvement to operational practices; or technologies widely & strategically implemented across the organization.