Corinne MIller, PhD

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EMD Millipore
R&D Director of Virology & Microbiological Sciences
Corinne E. Miller, PhD, is R&D Director of Virology & Microbiological Sciences at MilliporeSigma. She has more than 25 years of experience in life sciences and bioprocessing. She leads a team conducting bacterial and viral clearance characterization for sterilizing and virus filtration, virus inactivation technologies, microbial integrity testing for single-use and sterile connection and sampling technologies, bioburden assessment, and efficacy for bio-therapeutic processing. Corinne began her career as a cellular and molecular biologist, and has led product development teams on assay and detection technologies for DNA sequencing, nucleic acid and protein detection, ELISA, cell-based gene expression, and influenza drug resistance. She has worked on instrument platforms for high-throughput imaging and array-based surface plasmon resonance. She has a BS in microbiology from the Pennsylvania State University and a PhD in cellular and molecular biology from the Massachusetts Institute of Technology.

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Figure 1: Batch manufacturing process vs. a low pH iVI process.
Technical
Continuous Process: Implementing Low pH Viral Inactivation in a Continuous Process

Viral inactivation (VI) is a critical step in ensuring the safety of monoclonal antibody (mAb), Fc fusion, and recombinant protein therapeutics and it is typically an important component of an overall virus control strategy for downstream biotherapeutic production processes. Considerations for successful implementation of an inline VI process are discussed in this article.