Matthew Hepburn, M.D.

U.S. Office of Science and Technology Policy, Executive Office of the President
Senior Advisor To the OSTP Director on Pandemic Prevention
Dr. Matthew Hepburn is currently a Senior Advisor to Director of the Office of Science and Technology Policy (OSTP) for pandemic preparedness. Previously, Dr. Hepburn was the Vaccine Development Lead for the Countermeasures Acceleration Group (CAG), formerly known as Operation Warp Speed, a partnership between the Departments of Health and Human Services (HHS) and Defense (DoD) founded in May 2020 to help accelerate the development of COVID-19 vaccines. Prior to this position, Dr. Hepburn served as the Joint Project Lead of Enabling Biotechnologies for the Joint Program Executive Office for CBRN Defense. In this role, he was responsible for establishing a start-to-finish capability to develop vaccines and therapeutic solutions against current future biological threats. Due to the creation of this foundational capability, the team implemented the DoD Vaccine Acceleration Project, which provides key investments to advance vaccines and antibody therapeutic efforts, with special emphasis on acceleration of manufacturing these products and clinical trials. Dr. Hepburn served 23 years in the United States Army as an infectious diseases physician, retiring as a Colonel. His final assignment was as a Program Manager at DARPA (2013-2019).

Concurrent with the first two years at DARPA, Dr. Hepburn also served on the research and development team at the newly Research, Development and Acquisitions Directorate at the Defense Health Agency. From 2010-2013, he served as Director of Medical Preparedness on the White House National Security Staff. Additional assignments have included Chief Medical Officer, Level 2 Treatment facility in Iraq (2009-2010), for which he earned a Bronze Star.

Prior to deployment, Dr. Hepburn was Clinical Research Director at the U.S. Army Medical Research Institute for Infectious Diseases (2007-2009), leading domestic and international clinical research efforts on biodefense products. This role entailed extensive service with the Cooperative Threat Reduction program in the republics of the former Soviet Union. Col. Hepburn was also an exchange officer to the United Kingdom (2005-2007) and internal medicine chief of residents at Brooke Army Medical Center (2000-2001) at Fort Sam Houston, Texas.
Dr. Hepburn completed his infectious disease fellowship and internal medicine residency training at Brooke Army Medical Center in San Antonio, Texas. He received his medical degree and undergraduate degree in biomedical engineering from Duke University.