WEBINAR: Closed-Loop Control with PAT and Bioreactor Digital Twin for Yield Optimization
15 July 2025
5.30-6.30pm SGT | Online
Hosted by:
Abstract:
The integration of Process Analytical Technology (PAT) and Digital Twin applications offers a powerful approach to optimizing and stabilizing yield in fermenter operations. By enabling real-time component quantification within the fermenter through PAT and interfacing with a Digital Twin, this solution facilitates data-driven process adjustments to enhance efficiency and performance. The spectral data collected by the RAMAN PAT analyser is processed within the PAT application, where chemometric models determine the component attributes present in the fermenter. The component attributes and fermenter operating parameters are transmitted to a Digital Twin Platform, which predicts future conditions within the fermenter and determines the optimal substrate injection rate to maximize yield based on predicted conditions. The model’s recommended set point can then be utilized for substrate injection control, ensuring a more adaptive and efficient fermentation process.
Led by:
Chittimalla Mallaiah, Associate Director (ISG Consulting), Cognizant
Chittimalla Mallaiah is a seasoned consultant and Chemical Engineer with over 21 years of expertise in Process Engineering and Manufacturing Digitalization. Specializing in digital transformation, he helps businesses integrate advanced technologies to enhance operational efficiency, optimize production, and drive innovation. With a deep understanding of Industry 4.0, smart factories, and process automation, Chittimalla empowers manufacturers to embrace data-driven strategies for sustained growth and competitive advantage.
Aurelien Martin, Associate Director - Consulting for Life Science Manufacturing, Cognizant
A recognized manufacturing system lead with an entire career dedicated to the pharmaceutical industry, designing IT/OT solutions and optimizing manufacturing processes for efficiency and compliance optimization. Subject Matter Expert in Chemical Process, Biochemical Process, MES, Automation, Validation.