1. In-line Process Analytical Technology (PAT) tools in the bio-manufacturing process facilitate the process understanding.
2. Control of process parameter by PAT tools contributes to ensuring the quality of final products.
3. Raman spectroscopy as an accepted PAT tool in the biopharmaceutical industry.
Yusuke Tomioka, Senior Upstream Engineer, Asia Life Science MSAT, Merck
Yusuke Tomioka is senior upstream engineer in Asia Life science MSAT group (Manufacturing Science & Technology). His main roles are the development of biopharmaceutical process, process optimization, implementations, scale up and troubleshooting. Focusing mainly on pilot and manufacturing scale areas especially for the bioreactor. He joined Merck in 2013 and carried out process optimization for cell culture media and depth filtration, sterilization. He obtained a master’s degree in medicine from the Nagoya University (Japan).