ISPE Glossary of Pharmaceutical and Biotechnology Terminology

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The plural of Bacterium


Single-celled microorganisms measured in high purity water by several means: culturing, high power microscope, or Scanning Electron Microscope (SEM). The value is reported as Colony Forming Units (CFU), or colonies per milliliter or per liter. The bacteria in the water act as particle contamination on the surface of the product, or as a source of detrimental by-products.

Publication Source: ISPE Baseline® Guide, Vol. 4: Water and Steam Systems (Second Edition)

Publication Date: 2011

See also: Pyrogen

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