White Paper — Sponsored Content

Utilization of Novel kLa Measurement Procedure for Bioreactor Characterization & Optimization

Thomas Maischberger, PhD
Utilization of a Novel kLa Measurement Procedure

Abstract

Today, in line with the evolution of bioprocessing techniques to satisfy the concepts on Pharma 4.0, there is heavy emphasis on cell line and expression system improvements. Against this background, the demands on bioreactors have become ever more exacting over recent years, requiring paradigm shifts in manufacturing efficiencies. Continuous optimization, design improvements and characterization of bioreactors are crucial factors placing high demands for innovation in biopharmaceutical manufacturing. Therefore, it is inevitable that a focus is placed on new approaches in plant engineering to keep pace with the technological developments of the biopharmaceutical industry.

The mass transfer coefficient (kL)and the value of the interfacial area (a), is used to characterize bioreactor systems for their oxygen transfer capability. The kLa-value and the mixing time are amongst the most important performance indicators for bioreactors. The calculation and modelling of the kLa-value and mixing time is extremely complex in highly aerated systems.

This paper describes a new methodology for measuring the kLa value, to accurately determine the coefficient. The valuable insights obtained allow for improved bioreactor characterisation, thus making it easier to meet regulatory requirements. Furthermore, this paper cites three case studies outlining the benefits in the practical application of the new methodology.

Download White Paper


To download this white paper, complete the form below. Once submitted, you will receive a link via the email you provided to download the white paper.

Name
Company Type
Address

By completing this form, you consent to have your information provided to the third-party sponsor of this content and may use your information to provide information about relevant products, services, and other opportunities which may be of interest to you . ISPE will store your information in a secure environment and may use your information to provide information about relevant products, services, and other opportunities which may be of interest to you. You may unsubscribe from these ISPE communications at any time. For more information or to unsubscribe, review our Privacy Policy or contact us at ask@ispe.org.