Online TOC Comparison: Sensors and Analyzers
Pharmaceutical manufacturers rely on total organic carbon (TOC) measurements to meet compendial requirements for release of water and equipment for production. Accurate and consistent TOC analysis is critical to meet the acceptance criteria limits for USP regulations. Regulatory compliance may be achieved with a limit test. In this study, five TOC technologies were evaluated for performance and capability to be validated for pharmaceutical applications. Validated instruments that satisfy instrument qualification, method validation, and data integrity requirements are essential to reliable manufacturing processes.