PAT based Advanced Process Control and Monitoring applications for batch and continuous crystallization.

Crystallization is well understood within the industry, but often it is difficult to control quality, yield and particle size distribution. This presentation reviews a number of batch and continuous crystallization Advanced Process Control (APC) and monitoring applications. In each example Model Predictive Control, fault detection and data quality monitoring techniques are combined to deliver a robust and fail-safe application. 1. Understand the benefits from the integration of process control and statistical techniques. 2. Appreciate that closed loop control must be delivered in a robust, failsafe environment.